Let's face it, the more people you follow, the more challenging it gets to notice all important updates on Twitter. To me, following fewer people is not an option because I think this is anti-social. I follow back every single Twitter profile that seems valid and is related to one of the topics I love (like search, social media, blogging, etc). This way, as of today, I am close to following 3300 people which makes it really hard to really "follow" what everyone says.